Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.
J Exp Med
; 164(5): 1389-96, 1986 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-3464689
ABSTRACT
We report on a Ph+ chronic myelocytic leukemia (CML) case, cytogenetically characterized by the occurrence of a second Philadelphia (Ph) chromosome in lymphoid blast crisis of T cell lineage. In situ hybridization analyses showed a deletion of translocated c-abl sequences, present on the Ph during chronic state, from both Ph in acute state. Moreover, Southern blot analyses of blastic cells exhibited a rearrangement within bcr, but a deletion of 5' bcr sequences, and Northern blots failed to detect the hybrid 8.5 kb bcr/c-abl transcript usually observed in Ph+ CML.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
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Recombinação Genética
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Cromossomos Humanos Par 9
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Cromossomos Humanos Par 22
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Crise Blástica
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Leucemia Mieloide
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Deleção Cromossômica
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1986
Tipo de documento:
Article