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Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
Jones, J Howard; Xin, Zhili; Himmelbauer, Martin; Dechantsreiter, Michael; Enyedy, Istvan; Hedde, Joseph; Fang, Terry; Coomaraswamy, Janaky; King, Kristopher W; Murugan, Paramasivam; Santoro, Joseph C; Hesson, Thomas; Walther, Dirk M; Wei, Ru; Zheng, Fengmei; Marcotte, Douglas J; Spilker, Kerri; Kumar, P Rajesh; Liu, Ying; Gilfillan, Rab; Gonzalez-Lopez de Turiso, Felix.
Afiliação
  • Jones JH; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Xin Z; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Himmelbauer M; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Dechantsreiter M; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Enyedy I; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Hedde J; Acute Neurology Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Fang T; Acute Neurology Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Coomaraswamy J; Movement Disorders Research Unit, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • King KW; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Murugan P; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Santoro JC; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Hesson T; Bioassays, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Walther DM; Chemical Biology and Proteomics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Wei R; Chemical Biology and Proteomics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Zheng F; Technical Development, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Marcotte DJ; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Spilker K; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Kumar PR; Physical Biochemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Liu Y; Drug Metabolism and Pharmacokinetics, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Gilfillan R; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
  • Gonzalez-Lopez de Turiso F; Medicinal Chemistry, Biogen, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
J Med Chem ; 64(20): 15402-15419, 2021 10 28.
Article em En | MEDLINE | ID: mdl-34653340
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Encéfalo / MAP Quinase Quinase Quinase 5 / Inibidores de Proteínas Quinases / Descoberta de Drogas / Inflamação Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Encéfalo / MAP Quinase Quinase Quinase 5 / Inibidores de Proteínas Quinases / Descoberta de Drogas / Inflamação Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos