Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging.

Lee, Meelim J; Wang, Chuangqi; Carroll, Molly J; Brubaker, Douglas K; Hyman, Bradley T; Lauffenburger, Douglas A

Lee, Meelim J; Wang, Chuangqi; Carroll, Molly J; Brubaker, Douglas K; Hyman, Bradley T; Lauffenburger, Douglas A.

Afiliação

Lee MJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Wang C; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Carroll MJ; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States.
Brubaker DK; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States.
Hyman BT; Regenstrief Center for Healthcare Engineering, Purdue University, West Lafayette, IN, United States.
Lauffenburger DA; MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA, United States.

Front Neurosci ; 15: 727784, 2021.

Article em En | MEDLINE | ID: mdl-34658769

Palavras-chave

Alzheimer's disease; TAM receptor agonists; cross-species analysis; systems biology; transcriptomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Neurosci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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