Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.

Nguyen, Huy H; Tahirovic, Yesim A; Truax, Valarie M; Wilson, Robert J; Jecs, Edgars; Miller, Eric J; Kim, Michelle B; Akins, Nicholas S; Xu, Lingjie; Jiang, Yi; Wang, Tao; Sum, Chi S; Cvijic, Mary E; Schroeder, Gretchen M; Wilson, Lawrence J; Liotta, Dennis C

Nguyen, Huy H; Tahirovic, Yesim A; Truax, Valarie M; Wilson, Robert J; Jecs, Edgars; Miller, Eric J; Kim, Michelle B; Akins, Nicholas S; Xu, Lingjie; Jiang, Yi; Wang, Tao; Sum, Chi S; Cvijic, Mary E; Schroeder, Gretchen M; Wilson, Lawrence J; Liotta, Dennis C.

Afiliação

Nguyen HH; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Tahirovic YA; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Truax VM; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Wilson RJ; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Jecs E; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Miller EJ; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Kim MB; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Akins NS; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Xu L; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China.
Jiang Y; Hangzhou Junrui Biotechnology, Hangzhou, Zhejiang 310000, China.
Wang T; Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States.
Sum CS; Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States.
Cvijic ME; Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States.
Schroeder GM; Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States.
Wilson LJ; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.
Liotta DC; Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.

ACS Med Chem Lett ; 12(10): 1605-1612, 2021 Oct 14.

Article em En | MEDLINE | ID: mdl-34676043

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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