Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.

Pawlik, Marek J; Aldana, Blanca I; Belfiori-Carrasco, Lautaro F; Obara-Michlewska, Marta; Popek, Mariusz P; Czarnecka, Anna Maria; Albrecht, Jan

Pawlik, Marek J; Aldana, Blanca I; Belfiori-Carrasco, Lautaro F; Obara-Michlewska, Marta; Popek, Mariusz P; Czarnecka, Anna Maria; Albrecht, Jan.

Afiliação

Pawlik MJ; Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Aldana BI; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Belfiori-Carrasco LF; Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Obara-Michlewska M; Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Popek MP; Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Czarnecka AM; Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.
Albrecht J; Department of Neurotoxicology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warsaw, Poland.

Int J Mol Sci ; 22(20)2021 Oct 15.

Article em En | MEDLINE | ID: mdl-34681786

Assuntos

Encéfalo/efeitos dos fármacos; Ácido Glutâmico/metabolismo; Glutamina/metabolismo; Metionina Sulfoximina/farmacologia; Convulsões; Animais; Encéfalo/metabolismo; Progressão da Doença; Relação Dose-Resposta a Droga; Lítio/efeitos adversos; Masculino; Metionina Sulfoximina/administração & dosagem; Pilocarpina/efeitos adversos; Ratos; Ratos Sprague-Dawley; Via Secretória/efeitos dos fármacos; Convulsões/induzido quimicamente; Convulsões/tratamento farmacológico; Convulsões/metabolismo; Convulsões/patologia

Palavras-chave

epilepsy; glutamatergic transmission; glutamine synthesis; metabolomics; methionine sulfoximine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Encéfalo / Ácido Glutâmico / Glutamina / Metionina Sulfoximina Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Polônia

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