Your browser doesn't support javascript.
loading
Cold exposure protects from neuroinflammation through immunologic reprogramming.
Spiljar, Martina; Steinbach, Karin; Rigo, Dorothée; Suárez-Zamorano, Nicolas; Wagner, Ingrid; Hadadi, Noushin; Vincenti, Ilena; Page, Nicolas; Klimek, Bogna; Rochat, Mary-Aude; Kreutzfeldt, Mario; Chevalier, Claire; Stojanovic, Ozren; Bejuy, Olivia; Colin, Didier; Mack, Matthias; Cansever, Dilay; Greter, Melanie; Merkler, Doron; Trajkovski, Mirko.
Afiliação
  • Spiljar M; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Steinbach K; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Rigo D; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Suárez-Zamorano N; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Wagner I; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Hadadi N; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Vincenti I; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Page N; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Klimek B; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Rochat MA; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Kreutzfeldt M; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland.
  • Chevalier C; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Stojanovic O; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Bejuy O; CIBM Centre for BioMedical Imaging, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
  • Colin D; Small Animal Preclinical Imaging Platform, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.
  • Mack M; Department of Internal Medicine II - Nephrology, University Hospital Regensburg, Regensburg, Germany.
  • Cansever D; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Greter M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Merkler D; Department of Pathology and Immunology, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland. Electronic address: doron.merkler@unige.ch.
  • Trajkovski M; Department of Cell Physiology and Metabolism, Faculty of Medicine, Centre Médical Universitaire (CMU), University of Geneva, Geneva, Switzerland; Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Electronic address: mirko.trajkovski@unige.ch.
Cell Metab ; 33(11): 2231-2246.e8, 2021 11 02.
Article em En | MEDLINE | ID: mdl-34687652
ABSTRACT
Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactive T cells. Here, we provide unbiased analysis of the immune changes in various compartments during cold exposure and show that this energetically costly stimulus markedly ameliorates active experimental autoimmune encephalomyelitis (EAE). Cold exposure decreases MHCII on monocytes at steady state and in various inflammatory mouse models and suppresses T cell priming and pathogenicity through the modulation of monocytes. Genetic or antibody-mediated monocyte depletion or adoptive transfer of Th1- or Th17-polarized cells for EAE abolishes the cold-induced effects on T cells or EAE, respectively. These findings provide a mechanistic link between environmental temperature and neuroinflammation and suggest competition between cold-induced metabolic adaptations and autoimmunity as energetic trade-off beneficial for the immune-mediated diseases.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Doenças Neuroinflamatórias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalomielite Autoimune Experimental / Doenças Neuroinflamatórias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça