Three-dimensional organoid culture unveils resistance to clinical therapies in adult and pediatric glioblastoma.

Sundar, Swetha J; Shakya, Sajina; Barnett, Austin; Wallace, Lisa C; Jeon, Hyemin; Sloan, Andrew; Recinos, Violette; Hubert, Christopher G

Sundar, Swetha J; Shakya, Sajina; Barnett, Austin; Wallace, Lisa C; Jeon, Hyemin; Sloan, Andrew; Recinos, Violette; Hubert, Christopher G.

Afiliação

Sundar SJ; Department of Neurological Surgery, Cleveland Clinic, 9500 Euclid Avenue, ND2-40, Cleveland, OH, USA.
Shakya S; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Barnett A; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Wallace LC; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Jeon H; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Sloan A; Department of Neurological Surgery, University Hospitals Case Medical Center, Seidman Cancer Center and Case Comprehensive Cancer Center, Cleveland, OH, USA.
Recinos V; Department of Neurological Surgery, Cleveland Clinic, 9500 Euclid Avenue, ND2-40, Cleveland, OH, USA.
Hubert CG; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address: hubertc@ccf.org.

Transl Oncol ; 15(1): 101251, 2022 Jan.

Article em En | MEDLINE | ID: mdl-34700192

Palavras-chave

Chemotherapy; Glioblastoma; Organoids; Therapeutic resistance; Tumor microenvironments

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Transl Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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