Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection.
Science
; 374(6568): eabe6723, 2021 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-34735226
ABSTRACT
A diverse group of antimicrobial proteins (AMPs) helps protect the mammalian intestine from varied microbial challenges. We show that small proline-rich protein 2A (SPRR2A) is an intestinal antibacterial protein that is phylogenetically unrelated to previously discovered mammalian AMPs. In this study, SPRR2A was expressed in Paneth cells and goblet cells and selectively killed Gram-positive bacteria by disrupting their membranes. SPRR2A shaped intestinal microbiota composition, restricted bacterial association with the intestinal surface, and protected against Listeria monocytogenes infection. SPRR2A differed from other intestinal AMPs in that it was induced by type 2 cytokines produced during helminth infection. Moreover, SPRR2A protected against helminth-induced bacterial invasion of intestinal tissue. Thus, SPRR2A is a distinctive AMP triggered by type 2 immunity that protects the intestinal barrier during helminth infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nematospiroides dubius
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Infecções por Strongylida
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Proteínas Ricas em Prolina do Estrato Córneo
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Microbioma Gastrointestinal
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Bactérias Gram-Positivas
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Mucosa Intestinal
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Intestinos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos