Superfood for axons: Glial exosomes boost axonal energetics by delivery of SIRT2.
Neuron
; 109(21): 3397-3400, 2021 11 03.
Article
em En
| MEDLINE
| ID: mdl-34735790
ABSTRACT
Axon integrity depends on support by glia facilitating axonal maintenance and energy homeostasis, but the molecular mechanisms are not well understood. In this issue of Neuron, Chamberlain et al. (2021) provide evidence that oligodendrocyte-to-axon transfer of SIRT2 via extracellular vesicles (exosomes) enables deacetylation of mitochondrial proteins, enhancing axonal energy production.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exossomos
/
Sirtuína 2
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article