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Disruption of HIV-1 co-receptors CCR5 and CXCR4 in primary human T cells and hematopoietic stem and progenitor cells using base editing.
Knipping, Friederike; Newby, Gregory A; Eide, Cindy R; McElroy, Amber N; Nielsen, Sarah C; Smith, Kyle; Fang, Yongxing; Cornu, Tatjana I; Costa, Caroline; Gutierrez-Guerrero, Alejandra; Bingea, Samuel P; Feser, Colby J; Steinbeck, Benjamin; Hippen, Keli L; Blazar, Bruce R; McCaffrey, Anton; Mussolino, Claudio; Verhoeyen, Els; Tolar, Jakub; Liu, David R; Osborn, Mark J.
Afiliação
  • Knipping F; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  • Eide CR; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • McElroy AN; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Nielsen SC; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Smith K; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Fang Y; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; MD Program, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany
  • Cornu TI; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; Faculty of Medicine, University of Freiburg 79106, Germany.
  • Costa C; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France.
  • Gutierrez-Guerrero A; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France.
  • Bingea SP; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Feser CJ; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Steinbeck B; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Hippen KL; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Blazar BR; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • McCaffrey A; TriLink BioTechnologies, San Diego, CA 92121, USA.
  • Mussolino C; Institute for Transfusion Medicine and Gene Therapy, Medical Center, University of Freiburg, Freiburg 79106, Germany; Center for Chronic Immunodeficiency, Medical Center, University of Freiburg, Freiburg 79106, Germany; Faculty of Medicine, University of Freiburg 79106, Germany.
  • Verhoeyen E; CIRI - International Center for Infectiology Research, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, Ecole Normale Supérieure de Lyon, Université Lyon, F-69007 Lyon, France; Université Côte d'Azur, INSERM, C3M, 06204 Nice, France.
  • Tolar J; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA.
  • Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.
  • Osborn MJ; Medical School, Department of Pediatrics, Division of Blood and Marrow Transplant & Cellular Therapy, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: osbor026@umn.edu.
Mol Ther ; 30(1): 130-144, 2022 01 05.
Article em En | MEDLINE | ID: mdl-34737067
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CCR5 / Receptores CXCR4 / Edição de Genes Limite: Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores CCR5 / Receptores CXCR4 / Edição de Genes Limite: Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos