The surgical challenge of oligometastatic pancreatic cancer: A systemic review of the literature.

ABSTRACT

PURPOSE: We aim to review the available literature on surgical management of oligometastatic pancreatic ductal adenocarcinoma (PDAC), in order to assess the clinical outcomes and intraoperative parameters of the different strategies. METHODS: A systematic literature search was performed in PubMed database, in accordance with the PRISMA guidelines. Nine studies met the inclusion criteria incorporating 401 patients. RESULTS: Perioperative mortality was as low as 0%, regarding resection of pancreatic cancer combined with synchronous metastasectomy. CONCLUSIONS: Currently, postoperative overall survival and progression-free survival have increased compared to previous trials. Nevertheless, the lack of precise operative indications delays the enhancement of survival rates. Well-designed, randomized controlled studies, assessing pancreatic surgery combined with metastasectomy, are necessary to further assess their clinical outcomes.