Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy.
Epilepsy Behav
; 125: 108402, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34775249
ABSTRACT
OBJECTIVE:
To determine the characteristics of olfactory dysfunction in patients with temporal lobe epilepsy (TLE).METHODS:
Odor identification was assessed using the odor stick identification test for Japanese (OSIT-J, full score 12 points) in 65 patients with TLE and in 74 controls.RESULTS:
The mean OSIT-J score was significantly lower in patients with TLE (mean⯱â¯SDâ¯=â¯8.1⯱â¯2.8; medianâ¯=â¯9) than in the control subjects (mean⯱â¯SDâ¯=â¯10.6⯱â¯1.1; medianâ¯=â¯11) (Pâ¯<â¯0.005). Olfactory dysfunction (hyposmia/anosmia) was associated with bilateral seizure foci and older age of onset in TLE. Patients who underwent temporal lobectomy for hippocampal sclerosis did not show significant decline after long-term recovery. The Indian ink part of OSIT-J was useful for the detection of olfactory deficits in patients with TLE (sensitivityâ¯=â¯47%, specificityâ¯=â¯93%). Patients with TLE tended to have preserved olfactory ability for stimulating odors and for familiar odors of daily life.SIGNIFICANCE:
We observed characteristic odor identification deficits for individual odors used in OSIT-J. Our study findings provide deeper insight into the underlying mechanism of olfactory function in patients with TLE and may be beneficial in the clinical management of these patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsia do Lobo Temporal
/
Transtornos do Olfato
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Aged
/
Humans
Idioma:
En
Revista:
Epilepsy Behav
Assunto da revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão