Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer.
Clin Cancer Res
; 28(4): 708-718, 2022 02 15.
Article
em En
| MEDLINE
| ID: mdl-34789479
ABSTRACT
PURPOSE:
Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized Therapy) was a pilot feasibility trial aiming to prospectively generate patient-derived organoids (PDO) from patients with PDAC and test their drug sensitivity and correlation with clinical outcomes. EXPERIMENTALDESIGN:
PDOs were established from a heterogeneous population of patients with PDAC including both basal and classical PDAC subtypes.RESULTS:
A method for classifying PDOs as sensitive or resistant to chemotherapy regimens was developed to predict the clinical outcome of patients. Drug sensitivity testing on PDOs correlated with clinical responses to treatment in individual patients.CONCLUSIONS:
These data support the investigation of PDOs to guide treatment in prospective interventional trials in PDAC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Carcinoma Ductal Pancreático
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Clin Cancer Res
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2022
Tipo de documento:
Article