Diffuse idiopathic skeletal hyperostosis is associated with incident stroke in patients with increased cardiovascular risk.
Rheumatology (Oxford)
; 61(7): 2867-2874, 2022 07 06.
Article
em En
| MEDLINE
| ID: mdl-34791065
ABSTRACT
OBJECTIVES:
Earlier retrospective studies have suggested a relation between DISH and cardiovascular disease, including myocardial infarction. The present study assessed the association between DISH and incidence of cardiovascular events and mortality in patients with high cardiovascular risk.METHODS:
In this prospective cohort study, we included 4624 patients (mean age 58.4 years, 69.6% male) from the Second Manifestations of ARTerial disease cohort. The main end point was major cardiovascular events (MACE stroke, myocardial infarction and vascular death). Secondary endpoints included all-cause mortality and separate vascular events. Cause-specific proportional hazard models were used to evaluate the risk of DISH on all outcomes, and subdistribution hazard models were used to evaluate the effect of DISH on the cumulative incidence. All models were adjusted for age, sex, body mass index, blood pressure, diabetes, non-HDL cholesterol, packyears, renal function and C-reactive protein.RESULTS:
DISH was present in 435 (9.4%) patients. After a median follow-up of 8.7 (IQR 5.0-12.0) years, 864 patients had died and 728 patients developed a MACE event. DISH was associated with an increased cumulative incidence of ischaemic stroke. After adjustment in cause-specific modelling, DISH remained significantly associated with ischaemic stroke (HR 1.55; 95% CI 1.01, 2.38), but not with MACE (HR 0.99; 95% CI 0.79, 1.24), myocardial infarction (HR 0.88; 95% CI 0.59, 1.31), vascular death (HR 0.94; 95% CI 0.68, 1.27) or all-cause mortality (HR 0.94; 95% CI 0.77, 1.16).CONCLUSION:
The presence of DISH is independently associated with an increased incidence and risk for ischaemic stroke, but not with MACE, myocardial infarction, vascular death or all-cause mortality.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Isquemia Encefálica
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Acidente Vascular Cerebral
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Hiperostose Esquelética Difusa Idiopática
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AVC Isquêmico
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Infarto do Miocárdio
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Rheumatology (Oxford)
Assunto da revista:
REUMATOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article