A glucagon analogue decreases body weight in mice via signalling in the liver.

Hinds, Charlotte E; Owen, Bryn M; Hope, David C D; Pickford, Philip; Jones, Ben; Tan, Tricia M; Minnion, James S; Bloom, Stephen R

Hinds, Charlotte E; Owen, Bryn M; Hope, David C D; Pickford, Philip; Jones, Ben; Tan, Tricia M; Minnion, James S; Bloom, Stephen R.

Afiliação

Hinds CE; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Owen BM; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Hope DCD; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Pickford P; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Jones B; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Tan TM; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Minnion JS; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Bloom SR; Section of Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK. s.bloom@imperial.ac.uk.

Sci Rep ; 11(1): 22577, 2021 11 19.

Article em En | MEDLINE | ID: mdl-34799628

Assuntos

Fármacos Antiobesidade/farmacologia; Glucagon/farmacologia; Hepatócitos/efeitos dos fármacos; Fígado/efeitos dos fármacos; Receptores de Glucagon/agonistas; Redução de Peso/efeitos dos fármacos; Animais; Fármacos Antiobesidade/farmacocinética; Variação Biológica da População; Relação Dose-Resposta a Droga; Feminino; Glucagon/análogos & derivados; Glucagon/farmacocinética; Células HEK293; Hepatócitos/metabolismo; Humanos; Fígado/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Ratos Wistar; Receptores de Glucagon/genética; Receptores de Glucagon/metabolismo; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucagon / Redução de Peso / Receptores de Glucagon / Fármacos Antiobesidade / Hepatócitos / Fígado Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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