Your browser doesn't support javascript.
loading
Kidney dysfunction requiring dialysis is a heterogeneous syndrome: we should treat it like one.
Murea, Mariana; Flythe, Jennifer E; Anjay, Rastogi; Emaad, Abdel-Rahman M; Gupta, Nupur; Kovach, Cassandra; Vachharajani, Tushar J; Kalantar-Zadeh, Kamyar; Casino, Francesco G; Basile, Carlo.
Afiliação
  • Murea M; Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem.
  • Flythe JE; University of North Carolina (UNC) Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, UNC School of Medicine.
  • Anjay R; Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, North Carolina.
  • Emaad AM; Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
  • Gupta N; Division of Nephrology, University of Virginia Health System, Charlottesville, Virginia.
  • Kovach C; Indiana University Health, Indianapolis, Indiana.
  • Vachharajani TJ; Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
  • Kalantar-Zadeh K; Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
  • Casino FG; Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine, Orange, California, USA.
  • Basile C; Clinical Research Branch, Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti.
Curr Opin Nephrol Hypertens ; 31(1): 92-99, 2022 01 01.
Article em En | MEDLINE | ID: mdl-34846314
PURPOSE OF REVIEW: Advanced kidney failure requiring dialysis, commonly labeled end-stage kidney disease or chronic kidney disease stage 5D, is a heterogeneous syndrome -a key reason that may explain why: treating advanced kidney dysfunction is challenging and many clinical trials involving patients on dialysis have failed, thus far. Treatment with dialytic techniques - of which maintenance thrice-weekly hemodialysis is most commonly used - is broadly named kidney 'replacement' therapy, a term that casts the perception of a priori abandonment of intrinsic kidney function and subsumes patients into a single, homogeneous group. RECENT FINDINGS: Patients with advanced kidney failure necessitating dialytic therapy may have ongoing endogenous kidney function, and differ in their clinical manifestations and needs. Different terminology, for example, kidney dysfunction requiring dialysis (KDRD) with stages of progressive severity could better capture the range of phenotypes of patients who require kidney 'assistance' therapy. SUMMARY: Classifying patients with KDRD based on objective, quantitative levels of endogenous kidney function, as well as patient-reported symptoms and quality of life, would facilitate hemodialysis prescriptions tailored to level of kidney dysfunction, clinical needs, and personal priorities. Such classification would encourage clinicians to move toward personalized, physiological, and adaptive approach to hemodialysis therapy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Renal / Falência Renal Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Curr Opin Nephrol Hypertens Assunto da revista: ANGIOLOGIA / NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diálise Renal / Falência Renal Crônica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Curr Opin Nephrol Hypertens Assunto da revista: ANGIOLOGIA / NEFROLOGIA Ano de publicação: 2022 Tipo de documento: Article