SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix.
Mol Cell Oncol
; 8(5): 1976583, 2021.
Article
em En
| MEDLINE
| ID: mdl-34859141
ABSTRACT
Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy production, and ultimately the survival of ECM-detached cells. Abbreviations ECM, extracellular matrix; SGK1, serum and glucocorticoid kinase-1; ROS, reactive oxygen species; CCCP, cyanide m-chlorophenyl hydrazine; PPP, pentose phosphate pathway; G3P, glyceraldhyde-3-phosphate; shRNA, short hairpin RNA; TCA, tricarboxylic acid.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mol Cell Oncol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos