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Loss of MED12 activates the TGFß pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.
Jackson, Lindsey M; Dhoonmoon, Ashna; Hale, Anastasia; Dennis, Kady A; Schleicher, Emily M; Nicolae, Claudia M; Moldovan, George-Lucian.
Afiliação
  • Jackson LM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Dhoonmoon A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Hale A; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Dennis KA; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Schleicher EM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Nicolae CM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
  • Moldovan GL; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nucleic Acids Res ; 49(22): 12855-12869, 2021 12 16.
Article em En | MEDLINE | ID: mdl-34871431
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Resistencia a Medicamentos Antineoplásicos / Proteína BRCA1 / Proteína BRCA2 / Replicação do DNA / Complexo Mediador Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Resistencia a Medicamentos Antineoplásicos / Proteína BRCA1 / Proteína BRCA2 / Replicação do DNA / Complexo Mediador Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos