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Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1.
Boyd, Michael J; Collier, Philip N; Clark, Michael P; Deng, Hongbo; Kesavan, Sarathy; Ronkin, Steven M; Waal, Nathan; Wang, Jian; Cao, Jingrong; Li, Pan; Come, Jon; Davies, Ioana; Duffy, John P; Cochran, John E; Court, John J; Chandupatla, Kishan; Jackson, Katrina L; Maltais, Francois; O'Dowd, Hardwin; Boucher, Christina; Considine, Tony; Taylor, William P; Gao, Hong; Chakilam, Ananthisrinivas; Engtrakul, Juntyma; Crawford, Dan; Doyle, Elizabeth; Phillips, Jonathan; Kemper, Raymond; Swett, Rebecca; Empfield, James; Bunnage, Mark E; Charifson, Paul S; Magavi, Sanjay Shivayogi.
Afiliação
  • Boyd MJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Collier PN; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Clark MP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Deng H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Kesavan S; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Ronkin SM; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Waal N; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Wang J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Cao J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Li P; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Come J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Davies I; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Duffy JP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Cochran JE; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Court JJ; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Chandupatla K; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Jackson KL; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Maltais F; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • O'Dowd H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Boucher C; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Considine T; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Taylor WP; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Gao H; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Chakilam A; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Engtrakul J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Crawford D; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Doyle E; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Phillips J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Kemper R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Swett R; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Empfield J; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Bunnage ME; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Charifson PS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
  • Magavi SS; Vertex Pharmaceuticals Incorporated, 50 Northern Ave, Boston, Massachusetts 02210, United States.
J Med Chem ; 64(24): 17777-17794, 2021 12 23.
Article em En | MEDLINE | ID: mdl-34871500
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores Enzimáticos / Descoberta de Drogas / Elongases de Ácidos Graxos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores Enzimáticos / Descoberta de Drogas / Elongases de Ácidos Graxos Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos