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2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA.
Pantic, Boris; Ives, Daniel; Mennuni, Mara; Perez-Rodriguez, Diego; Fernandez-Pelayo, Uxoa; Lopez de Arbina, Amaia; Muñoz-Oreja, Mikel; Villar-Fernandez, Marina; Dang, Thanh-Mai Julie; Vergani, Lodovica; Johnston, Iain G; Pitceathly, Robert D S; McFarland, Robert; Hanna, Michael G; Taylor, Robert W; Holt, Ian J; Spinazzola, Antonella.
Afiliação
  • Pantic B; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.
  • Ives D; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.
  • Mennuni M; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.
  • Perez-Rodriguez D; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.
  • Fernandez-Pelayo U; Biodonostia Health Research Institute, 20014, San Sebastián, Spain.
  • Lopez de Arbina A; Biodonostia Health Research Institute, 20014, San Sebastián, Spain.
  • Muñoz-Oreja M; Biodonostia Health Research Institute, 20014, San Sebastián, Spain.
  • Villar-Fernandez M; Department of Pediatrics, Medicine and Nursing Faculty, Universidad de País Vasco, Bilbao, Spain.
  • Dang TJ; Biodonostia Health Research Institute, 20014, San Sebastián, Spain.
  • Vergani L; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK.
  • Johnston IG; Department of Neurosciences, University of Padova, 35128, Padova, Italy.
  • Pitceathly RDS; Faculty of Mathematics and Natural Sciences, University of Bergen, 5007, Bergen, Norway.
  • McFarland R; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK.
  • Hanna MG; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
  • Taylor RW; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, WC1N 3BG, UK.
  • Holt IJ; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
  • Spinazzola A; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Royal Free Campus, London, NW3 2PF, UK. ian.holt@biodonostia.org.
Nat Commun ; 12(1): 6997, 2021 12 06.
Article em En | MEDLINE | ID: mdl-34873176
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Mutação Puntual / Desoxiglucose / Replicação do DNA / Mitocôndrias Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Mutação Puntual / Desoxiglucose / Replicação do DNA / Mitocôndrias Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido