Growth hormone treatment does not to lead to insulin resistance nor excessive rise in IGF-1 levels, while improving height in patients small for gestational age A long-term observational study.
Clin Endocrinol (Oxf)
; 96(4): 558-568, 2022 04.
Article
em En
| MEDLINE
| ID: mdl-34882803
ABSTRACT
OBJECTIVE:
In children born small for gestational age (SGA), the relationship between growth hormone (GH) treatment and insulin resistance (IR) has only been investigated for a short period, necessitating a longer observation period. This study aimed to evaluate the long-term (10 years) effect of GH to SGA-children on IR and safety during treatment.DESIGN:
This was a multicenter observational study. PATIENTS SGA-children who received GH treatment in Spain (stratified by Tanner-stage and age at GH onset [two groups ≤6 years old or >6 years old]). MEASUREMENTS The analysed variables (yearly measures) included auxologic, metabolic (insulin-like growth factor-1 (IGF-1), height velocity [HV], weight and homeostatic model assessment-IR [HOMA-IR]) and safety data. Data were collected prospectively (since the study approval 2007) and retrospectively (since the initiation of GH treatment 2005-2007).RESULTS:
A total of 389 SGA children (369 Tanner-I) were recruited from 27 centres. The mean age (standard deviation) of the children at GH treatment onset was 7.2 (2.8) years old. IGF-1 (standard deviation score [SDS]) and HOMA-IR values tended to increase until the sixth year of GH-treatment, with significant differences being observed only during the first year, while these remained stable in the later years (within normal ranges). Height (SDS) increased significantly (basal -3.0; tenth year -1.13), and the maximum HV (SDS) occurred during the first year (2.75 ± 2.39).CONCLUSIONS:
HOMA-IR values increased significantly in SGA-children during the first year of GH-treatment, remained stable and were within normal ranges in all cases. Our 10-year data suggests that long-term GH treatment does not promote IR and is well-tolerated, safe and effective.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Resistência à Insulina
/
Fator de Crescimento Insulin-Like I
/
Hormônio do Crescimento Humano
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Child, preschool
/
Humans
/
Newborn
Idioma:
En
Revista:
Clin Endocrinol (Oxf)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Espanha