EBNA-negative polyclonal B cells derived from a long-term culture of unclassified acute lymphoblastic leukemia: IL-2-like activity of culture's supernatant.
Int J Cell Cloning
; 4(4): 263-73, 1986 Jul.
Article
em En
| MEDLINE
| ID: mdl-3489053
ABSTRACT
A long-term culture of bone marrow lymphoblasts in a case of unclassified acute lymphoblastic leukemia is described. Cells lacking any lymphocytic marker in the early phase of the culture were gradually substituted by B cells showing a pattern of polyclonality. The culture supernatant contained high levels of immunoglobulins also showing interleukin 2 activity. Search for antigens related to the Epstein-Barr virus was negative. A clonal expansion of B cells versus spontaneous differentiation of unclassified leukemic cells is discussed; the long-term culture technique as a tool for a better evaluation of leukemic cells is suggested and discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Leucemia Linfoide
/
Interleucina-2
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Int J Cell Cloning
Ano de publicação:
1986
Tipo de documento:
Article