Influence of ligand lipophilicity in Pt(II) complexes on their antiproliferative and apoptotic activities in tumour cell lines.

Fernández-Delgado, Elena; Estirado, Samuel; Espino, Javier; Viñuelas-Zahínos, Emilio; Luna-Giles, Francisco; Rodríguez Moratinos, Ana B; Pariente, José A

Fernández-Delgado, Elena; Estirado, Samuel; Espino, Javier; Viñuelas-Zahínos, Emilio; Luna-Giles, Francisco; Rodríguez Moratinos, Ana B; Pariente, José A.

Afiliação

Fernández-Delgado E; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), University of Extremadura, Badajoz, Spain.
Estirado S; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), University of Extremadura, Badajoz, Spain.
Espino J; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), University of Extremadura, Badajoz, Spain. Electronic address: jespino@unex.es.
Viñuelas-Zahínos E; Department of Organic and Inorganic Chemistry (Coordination Chemistry Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.
Luna-Giles F; Department of Organic and Inorganic Chemistry (Coordination Chemistry Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain. Electronic address: pacoluna@unex.es.
Rodríguez Moratinos AB; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), University of Extremadura, Badajoz, Spain.
Pariente JA; Department of Physiology (Neuroimmunophysiology and Chrononutrition Research Group), University of Extremadura, Badajoz, Spain.

J Inorg Biochem ; 227: 111688, 2022 02.

Article em En | MEDLINE | ID: mdl-34922157

Assuntos

Antineoplásicos; Proliferação de Células/efeitos dos fármacos; Complexos de Coordenação; Neoplasias; Platina; Antineoplásicos/química; Antineoplásicos/farmacocinética; Antineoplásicos/farmacologia; Complexos de Coordenação/química; Complexos de Coordenação/farmacocinética; Complexos de Coordenação/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Células HL-60; Células HeLa; Humanos; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Platina/química; Platina/farmacologia; Células U937

Palavras-chave

Apoptosis; Chemotherapeutics in tumour cells; Cytotoxicity; Lipophilicity; N,S-heterocycles; Pt(II) complexes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Platina / Proliferação de Células / Complexos de Coordenação / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Revista: J Inorg Biochem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Espanha

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