Design, synthesis, biological activity, molecular docking, and molecular dynamics of novel benzimidazole derivatives as potential AChE/MAO-B dual inhibitors.

Osmaniye, Derya; Evren, Asaf E; Saglik, Begüm N; Levent, Serkan; Özkay, Yusuf; Kaplancikli, Zafer A

Osmaniye, Derya; Evren, Asaf E; Saglik, Begüm N; Levent, Serkan; Özkay, Yusuf; Kaplancikli, Zafer A.

Afiliação

Osmaniye D; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Evren AE; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Saglik BN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Levent S; Vocational School of Health Services, Department of Pharmacy Services, Bilecik Seyh Edebali University, Bilecik, Turkey.
Özkay Y; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
Kaplancikli ZA; Doping and Narcotic Compounds Analysis Laboratory, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.

Arch Pharm (Weinheim) ; 355(3): e2100450, 2022 Mar.

Article em En | MEDLINE | ID: mdl-34931332

Assuntos

Acetilcolinesterase; Butirilcolinesterase; Acetilcolinesterase/metabolismo; Benzimidazóis/farmacologia; Butirilcolinesterase/metabolismo; Inibidores da Colinesterase/química; Cinética; Simulação de Acoplamento Molecular; Simulação de Dinâmica Molecular; Estrutura Molecular; Monoaminoxidase/metabolismo; Inibidores da Monoaminoxidase/química; Relação Estrutura-Atividade

Palavras-chave

Alzheimer's disease; benzimidazole; molecular docking; molecular dynamics; propargyl

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Butirilcolinesterase Idioma: En Revista: Arch Pharm (Weinheim) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Turquia

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