Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.

Qin, Jing; Sun, Xia; Ma, Yingang; Cheng, Yahong; Ma, Qiushuang; Jing, Weiqiang; Qu, Sifeng; Liu, Lei

Qin, Jing; Sun, Xia; Ma, Yingang; Cheng, Yahong; Ma, Qiushuang; Jing, Weiqiang; Qu, Sifeng; Liu, Lei.

Afiliação

Qin J; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao, Shandong 266237, China; School of Chemistry and C
Sun X; Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Ma Y; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Cheng Y; Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Ma Q; Department of Pharmacology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Jing W; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Qu S; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Department of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: qusifeng@sdu.edu.cn.
Liu L; School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. Electronic address: leiliu@sdu.edu.cn.

Bioorg Med Chem ; 55: 116594, 2021 Dec 31.

Article em En | MEDLINE | ID: mdl-34990979

Palavras-chave

1,3,4,9-Tetrahydropyrano[3,4-b] indoles; Apoptosis; Molecular hybridization; PI3K/AKT/mTOR pathway; Triple negative breast cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article

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