Acid secretion and cyclic nucleotide content of the guinea pig isolated stomach in the presence of the ionophore A23187.
Acta Hepatogastroenterol (Stuttg)
; 25(2): 155-7, 1978 Apr.
Article
em En
| MEDLINE
| ID: mdl-349995
ABSTRACT
The involvement of calcium ions in stimulus-secretion coupling in the gastric mucosa is uncertain. Acid secretion and mucosal cyclic nucleotide content of an isolated stomach preparation from the guinea-pig have been measured in the presence of the ionophore A2318 (Lilly) over the concentration range 10(-6) M both in the presence and absence of a phosphodiesterase inhibitor (ICI 631978 1 X 10(-4) M). The rate of acid secretion and cyclic nucleotide content were increased by ICI 63197 as expected but were unaltered by the ionophore. These results suggest that a change in intracellular calcium ion concentration does not alter acid secretion in this preparation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Fosfodiesterase
/
Calcimicina
/
Suco Gástrico
/
Mucosa Gástrica
/
Antibacterianos
/
Nucleotídeos Cíclicos
Limite:
Animals
Idioma:
En
Revista:
Acta Hepatogastroenterol (Stuttg)
Ano de publicação:
1978
Tipo de documento:
Article