Impaired antibody response to COVID-19 vaccination in advanced HIV infection.
AIDS
; 36(4): F1-F5, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-35013085
ABSTRACT
OBJECTIVES:
Coronavirus disease 2019 (COVID-19) vaccination is reportedly efficient in people with HIV (PWH) but vaccine trials included participants with normal CD4+ T-cell counts. We analyzed seroconversion rates and antibody titers following two-dose vaccination in PWH with impaired CD4+ T-cell counts.METHODS:
We collected retrospective postvaccination SARS-COV-2 serology results available in a university hospital for PWH vaccinated between March and September, 2021 who were tested for antispike antibodies from 8 to 150 days following dose 2. Antibody titers were compared in PWH with CD4+ T-cell count less than 200 cells/µl, 200â<âCD4+ T-cell countsâ<â500 cells/µl and CD4+ T-cell count greater than 500 cells/µl at vaccination.RESULTS:
One hundred and five PWH were included nâ=â54 in the CD4+ T-cell count less than 500 cells/µl group (nâ=â18 with CD4+ <200 cells/µl, nâ=â36 with 200â<âCD4+â<â500 cells/µl) and 51 in the CD4+ T-cell count greater than 500 cells/µl group. They received two doses of BNT162b2 (75%), mRNA-1273 (8.5%), or ChAdOx1 nCoV-19 (16.5%). The median time from vaccine dose 2 to serology was consistent across all groups (73âdays, interquartile range [29-97], Pâ=â0.14). Seroconversion rates were 100% in the CD4+ T-cell count greater than 500 cells/µl group but 89% in participants with CD4+ T-cell counts less than 500 cells/µl (22 and 5.5% seronegative in the CD4+ T-cell counts <200 cells/µl and 200â<âCD4+â<â500 cells/µl groups, respectively). Median antibody titers were 623.8âBAU/ml [262.2-2288] in the CD4+ greater than 500 cells/µl group versus 334.3âBAU/ml [69.9-933.9] in the CD4+ less than 500 cells/µl group (Pâ=â0.003). They were lowest in the CD4+ less than 200 cells/µl group 247.9âBAU/ml [5.88-434.9] (Pâ=â0.0017) with only 44% achieving antibody titers above the putative protection threshold of 260âBAU/ml.CONCLUSION:
PWH with CD4+ T-cell counts less than 500 cells/µl and notably less than 200 cells/µl had significantly lower seroconversion rates and antispike antibody titers compared with PWH with CD4+ T-cell counts greater than 500 cells/µl, warranting the consideration of targeted vaccine strategies in this fragile population.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
COVID-19
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2022
Tipo de documento:
Article