PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice.

de Jong, Laura M; Zhang, Zhengzheng; den Hartog, Yvette; Sijsenaar, Timothy J P; Martins Cardoso, Renata; Manson, Martijn L; Hankemeier, Thomas; Lindenburg, Peter W; Salvatori, Daniela C F; Van Eck, Miranda; Hoekstra, Menno

de Jong, Laura M; Zhang, Zhengzheng; den Hartog, Yvette; Sijsenaar, Timothy J P; Martins Cardoso, Renata; Manson, Martijn L; Hankemeier, Thomas; Lindenburg, Peter W; Salvatori, Daniela C F; Van Eck, Miranda; Hoekstra, Menno.

Afiliação

de Jong LM; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Zhang Z; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
den Hartog Y; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Sijsenaar TJP; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Martins Cardoso R; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Manson ML; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratories, 2333CC, Leiden, The Netherlands.
Hankemeier T; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Lindenburg PW; Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.
Salvatori DCF; Research Group Metabolomics, Leiden Center for Applied Bioscience, University of Applied Sciences Leiden, Leiden, The Netherlands.
Van Eck M; Central Laboratory Animal Facility, Leiden University Medical Center, Leiden, The Netherlands.
Hoekstra M; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Sci Rep ; 12(1): 483, 2022 01 10.

Article em En | MEDLINE | ID: mdl-35013582

Assuntos

Dieta Ocidental/efeitos adversos; Fígado Gorduroso/tratamento farmacológico; Isoquinolinas/efeitos adversos; Proteína-Arginina N-Metiltransferases/antagonistas & inibidores; Prurido/etiologia; Receptores de LDL/genética; Triglicerídeos/sangue; Animais; Fígado Gorduroso/metabolismo; Humanos; Isoquinolinas/uso terapêutico; Fígado/efeitos dos fármacos; Fígado/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Proteína-Arginina N-Metiltransferases/genética; Proteína-Arginina N-Metiltransferases/metabolismo; Prurido/genética; Prurido/metabolismo; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Receptores de LDL/deficiência

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Prurido / Triglicerídeos / Receptores de LDL / Fígado Gorduroso / Dieta Ocidental / Isoquinolinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda

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