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Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2-Thienyl-Substituted α-Ketoamide.
Moriyama, Takahiro; Mizukami, Daiki; Yoritate, Makoto; Usui, Kazuteru; Takahashi, Daisuke; Ota, Eisuke; Sodeoka, Mikiko; Ueda, Tadashi; Karasawa, Satoru; Hirai, Go.
Afiliação
  • Moriyama T; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
  • Mizukami D; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
  • Yoritate M; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
  • Usui K; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
  • Takahashi D; Faculty of Pharmaceutical Sciences, Showa Pharmaceutical University Higashi-Tamagawagakuen, Machida, Tokyo, 194-8543, Japan.
  • Ota E; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
  • Sodeoka M; RIKEN Cluster for Pioneering Research, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan.
  • Ueda T; RIKEN Cluster for Pioneering Research, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan.
  • Karasawa S; RIKEN Center for Sustainable Resource Science, 2-1, Hirosawa, Wako, Saitama, 351-0198, Japan.
  • Hirai G; Graduate School of Pharmaceutical Sciences, Kyushu University Maidashi Higashi-ku, Fukuoka, 812-8582, Japan.
Chemistry ; 28(11): e202103925, 2022 Feb 19.
Article em En | MEDLINE | ID: mdl-35023607
ABSTRACT
Minimalist photo-reactive probes, which consist of a photo-reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine-based and aryl azide-based minimalist probes are available, no keto-based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2-thienyl-substituted α-ketoamide bearing an alkyne group on the thiophene ring. The 3-alkyne probe showed the highest photo-affinity labeling efficiency.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Marcadores de Fotoafinidade Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Azidas / Marcadores de Fotoafinidade Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão