Role of miRNA polymorphism in recurrent pregnancy loss: a systematic review and meta-analysis.

Lay abstract miRNAs play a crucial role in the regulation of several biological processes and have an important role in recurrent pregnancy loss (RPL), proven by many studies. However, the results from these studies are highly inconsistent, prompting us to undertake the meta-analysis to explore the real association between different miRNAs and their SNPs, with a risk of spontaneous abortions/RPL. The impetus for conducting this meta-analysis was to obtain a more robust picture of the association between miRNA polymorphism and RPL risk. This study will aid the development of a biomarker panel in the future, for the early diagnosis and prognosis of RPL patients.