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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state.
Belenguer, Germán; Mastrogiovanni, Gianmarco; Pacini, Clare; Hall, Zoe; Dowbaj, Anna M; Arnes-Benito, Robert; Sljukic, Aleksandra; Prior, Nicole; Kakava, Sofia; Bradshaw, Charles R; Davies, Susan; Vacca, Michele; Saeb-Parsy, Kourosh; Koo, Bon-Kyoung; Huch, Meritxell.
Afiliação
  • Belenguer G; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Mastrogiovanni G; The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Pacini C; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Gleeson Building, Cambridge, CB2 1QR, UK.
  • Hall Z; Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, UK.
  • Dowbaj AM; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Arnes-Benito R; Biomolecular Medicine, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2AZ, UK.
  • Sljukic A; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Prior N; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Kakava S; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Bradshaw CR; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Davies S; The Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
  • Vacca M; The Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, CB2 1QN, UK.
  • Saeb-Parsy K; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Koo BK; Metabolic Research Laboratories, University of Cambridge, Cambridge, UK.
  • Huch M; Clinica Medica Cesare Frugoni, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Nat Commun ; 13(1): 334, 2022 01 17.
Article em En | MEDLINE | ID: mdl-35039505
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Ubiquitina-Proteína Ligases / Fígado / Neoplasias Hepáticas / Regeneração Hepática Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Ubiquitina-Proteína Ligases / Fígado / Neoplasias Hepáticas / Regeneração Hepática Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha