Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones <i>In Vitro</i>.

Kim, Hyun; Mori, Shigetarou; Kenri, Tsuyoshi; Suzuki, Yasuhiko

Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones In Vitro.

Kim, Hyun; Mori, Shigetarou; Kenri, Tsuyoshi; Suzuki, Yasuhiko.

Afiliação

Kim H; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Mori S; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Kenri T; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Suzuki Y; Division of Bioresources, Hokkaido Universitygrid.39158.36 International Institute for Zoonosis Control, Sapporo, Japan.

Antimicrob Agents Chemother ; 66(4): e0190221, 2022 04 19.

Article em En | MEDLINE | ID: mdl-35041504

Assuntos

Mycobacterium ulcerans; Quinolonas; DNA Girase/metabolismo; Farmacorresistência Bacteriana/genética; Fluoroquinolonas/farmacologia; Testes de Sensibilidade Microbiana; Simulação de Acoplamento Molecular; Mutação; Mycobacterium ulcerans/genética; Quinolonas/farmacologia

Palavras-chave

Buruli ulcer disease; DNA gyrase; Mycobacterium ulcerans; fluoroquinolone resistance; molecular docking study; supercoiling assay

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolonas / Mycobacterium ulcerans Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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