A 3D mathematical model of coupled stem cell-nutrient dynamics in myocardial regeneration therapy.
J Theor Biol
; 537: 111023, 2022 03 21.
Article
em En
| MEDLINE
| ID: mdl-35041851
ABSTRACT
Stem cell therapy is a promising treatment for the regeneration of myocardial tissue injured by an ischemic event. Mathematical modeling of myocardial regeneration via stem cell therapy is a challenging task, since the mechanisms underlying the processes involved in the treatment are not yet fully understood. Many aspects must be accounted for, such as the spread of stem cells and nutrients, chemoattraction, cell proliferation, stages of cell maturation, differentiation, angiogenesis, stochastic effects, just to name a few. In this paper we propose a 3D mathematical model with a free boundary that aims to provide a qualitative description of some main aspects of the stem cell regenerative therapy in a simplified scenario. The paper mainly focuses on the description of the shrinking of the necrotic core during treatment. The stem cell and nutrients dynamics are described through coupled reaction-diffusion problems. Proliferation, chemoattraction, tissue regeneration and nutrient consumption are included in the model.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Células-Tronco
/
Modelos Teóricos
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália