Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours.
Br J Psychiatry
; : 1-3, 2021 May 05.
Article
em En
| MEDLINE
| ID: mdl-35049467
ABSTRACT
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic 'disinhibition' phenotype. In a cohort of 117 individuals, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Br J Psychiatry
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália