Dependence of Protein Structure on Environment: FOD Model Applied to Membrane Proteins.
Membranes (Basel)
; 12(1)2021 Dec 30.
Article
em En
| MEDLINE
| ID: mdl-35054576
ABSTRACT
The natural environment of proteins is the polar aquatic environment and the hydrophobic (amphipathic) environment of the membrane. The fuzzy oil drop model (FOD) used to characterize water-soluble proteins, as well as its modified version FOD-M, enables a mathematical description of the presence and influence of diverse environments on protein structure. The present work characterized the structures of membrane proteins, including those that act as channels, and a water-soluble protein for contrast. The purpose of the analysis was to verify the possibility that an external force field can be used in the simulation of the protein-folding process, taking into account the diverse nature of the environment that guarantees a structure showing biological activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Membranes (Basel)
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Polônia