The relationship between NLR/PLR/LMR levels and survival prognosis in patients with non-small cell lung carcinoma treated with immune checkpoint inhibitors.
Medicine (Baltimore)
; 101(3): e28617, 2022 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-35060536
ABSTRACT
BACKGROUND:
The relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) and the dire prognosis of non-small cell lung carcinoma patients who received immune checkpoint inhibitors (ICIs) are not known yet.METHODS:
We screened the articles that meet the criteria from the database. The relationship between NLR/PLR/LMR levels and the survival and prognosis of non-small cell lung cancer patients treated with ICIs was analyzed. Summarize hazard ratio (HR) with 95% confidence interval (CI) to study progression-free survival (PFS) and overall survival (OS).RESULTS:
Thirty-four studies involving 3124 patients were enrolled in the final analysis. In short, high pre-treatment NLR was related to poor OS (HRâ=â2.13, 95% CI1.74-2.61, Pâ<â.001, I2â=â83.3%, Pâ<â.001) and PFS (HRâ=â1.77, 95% CI1.44-2.17, Pâ<â.001, I2â=â79.5%, Pâ<â.001). Simultaneously, high pre-treatment PLR was related to poor OS (HRâ=â1.49, 95% CI1.17-1.91, Pâ<â.001, I2â=â57.6%, Pâ=â.003) and PFS (HRâ=â1.62, 95% CI1.38-1.89, Pâ<â.001, I2â=â47.1%, Pâ=â.036). In all subgroup analysis, most subgroups showed that low LMR was related to poor OS (HRâ=â0.45, 95% CI 0.34-0.59, Pâ<â.001) and PFS (HRâ=â0.60, 95% CI 0.47-0.77, Pâ<â0.001, I2â=â0.0%, Pâ<â.001).CONCLUSION:
High pre-treatment NLR and pre-treatment PLR in non-small cell lung carcinoma patients treated with ICIs are associated with low survival rates. Low pre-treatment and post-treatment LMR are also related to unsatisfactory survival outcomes. However, the significance of post-treatment NLR and post-treatment PLR deserve further prospective research to prove.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Monócitos
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
/
Neutrófilos
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China