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The incidence and clinical features of familial pancreatic cancer in Korea.
Kim, Minseob; Kim, Hongbeom; Han, Youngmin; Sohn, Heeju; Lee, Mirang; Kang, Yoon Hyung; Kim, Hyeong Seok; Kwon, Wooil; Jang, Jin-Young.
Afiliação
  • Kim M; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim H; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Han Y; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Sohn H; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Lee M; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Kang YH; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Kim HS; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Kwon W; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
  • Jang JY; Departments of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
J Hepatobiliary Pancreat Sci ; 29(6): 659-669, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35064645
BACKGROUND: A history of familial pancreatic cancer (FPC) increases the incidence of pancreatic cancer (PC) among first-degree relatives. We aimed to determine the incidence of FPC and analyze its clinical characteristics. METHODS: Between 2010 and 2014, 1159 patients with PC were included in the study. We evaluated the incidence of FPC, clinicopathological features, and survival prognosis between FPC and non-FPC patients. We further analyzed the clinical outcomes of 389 patients with PC who underwent curative-intent surgery. RESULTS: Familial pancreatic cancer incidence was 3.1% (n = 36) among all patients with PC (n = 1159). FPC was diagnosed at an advanced clinical stage compared to non-FPC (P = .041). The tested variables and 5-year survival rate (5YSR) between FPC and non-FPC after propensity score matching had no differences (5YSR: 4.6% vs 2.6%, P = .834). Among PC patients who underwent curative-intent surgery (n = 389), FPC incidence was 1.8% (n = 7). FPC patients were older than non-FPC patients (75.3 ± 4.7 years vs 64.0 ± 9.9 years, P < .001). 5YSR tended to differ between FPC and non-FPC (14.3% vs 22.5%, P = .07) groups. CONCLUSION: Familial pancreatic cancer is diagnosed at an advanced stage, and FPC that has undergone resection is associated with older age or worse prognosis. A prospective nationwide pedigree registration system was required.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Hepatobiliary Pancreat Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: J Hepatobiliary Pancreat Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Coréia do Sul