Healthy and unhealthy aging on kidney structure and function: human studies.
Curr Opin Nephrol Hypertens
; 31(3): 228-234, 2022 05 01.
Article
em En
| MEDLINE
| ID: mdl-35067600
ABSTRACT
PURPOSE OF REVIEW This review is intended to provide an up-to-date analysis of the structural and functional alterations of the kidneys that accompany healthy and unhealthy aging in humans. Macro- and micro- structural changes and glomerular filtration rate (whole kidney and single nephron) accompanying aging will be stressed. RECENT FINDINGS:
Comparative findings concerning distribution of anatomic changes of the kidney healthy and unhealthy aging are reviewed. Challenges concerning definition of chronic kidney disease (CKD) in otherwise healthy aging patients are discussed. The complex interactions of CKD and aging are discussed. The role of podocyte dysbiosis in kidney aging is reviewed.SUMMARY:
Kidney aging is a complex phenomenon often difficult to distinguish from CKD. Nonetheless, phenotypes of healthy and unhealthy aging are evident. Much more information concerning the molecular characteristics of normal kidney aging and its relevance to chronic kidney disease is needed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Podócitos
/
Insuficiência Renal Crônica
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Curr Opin Nephrol Hypertens
Assunto da revista:
ANGIOLOGIA
/
NEFROLOGIA
Ano de publicação:
2022
Tipo de documento:
Article