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Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose.
Zhang, Lingtian; Moccia, Marialuisa; Briggs, David C; Bharate, Jaideep B; Lakkaniga, Naga Rajiv; Knowles, Phillip; Yan, Wei; Tran, Phuc; Kharbanda, Anupreet; Wang, Xiuqi; Leung, Yuet-Kin; Frett, Brendan; Santoro, Massimo; McDonald, Neil Q; Carlomagno, Francesca; Li, Hong-Yu.
Afiliação
  • Zhang L; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Moccia M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131 Napoli, Italia.
  • Briggs DC; Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.
  • Bharate JB; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Lakkaniga NR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States.
  • Knowles P; Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.
  • Yan W; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Tran P; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Kharbanda A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Wang X; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Leung YK; Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Frett B; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
  • Santoro M; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131 Napoli, Italia.
  • McDonald NQ; Signalling and Structural Biology Laboratory, The Francis Crick Institute, London NW1 1AT, U.K.
  • Carlomagno F; Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, London WC1E 7HX, U.K.
  • Li HY; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli "Federico II", 80131 Napoli, Italia.
J Med Chem ; 65(2): 1536-1551, 2022 01 27.
Article em En | MEDLINE | ID: mdl-35081714
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-ret / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Mutação Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-ret / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Mutação Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos