Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase.

Hsu, Chia Wei; Sowers, Mark L; Baljinnyam, Tuvshintugs; Herring, Jason L; Hackfeld, Linda C; Tang, Hui; Zhang, Kangling; Sowers, Lawrence C

Hsu, Chia Wei; Sowers, Mark L; Baljinnyam, Tuvshintugs; Herring, Jason L; Hackfeld, Linda C; Tang, Hui; Zhang, Kangling; Sowers, Lawrence C.

Afiliação

Hsu CW; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA; MD-PhD Combined Degree Program, University of Texas Medical Branch, Galveston, Texas, USA.
Sowers ML; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA; MD-PhD Combined Degree Program, University of Texas Medical Branch, Galveston, Texas, USA.
Baljinnyam T; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Herring JL; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Hackfeld LC; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Tang H; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Zhang K; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA.
Sowers LC; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA; Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA. Electronic address: lasowers@UTMB.edu.

J Biol Chem ; 298(3): 101638, 2022 03.

Article em En | MEDLINE | ID: mdl-35085553

Assuntos

DNA; Timina DNA Glicosilase; Citosina/química; Citosina/metabolismo; DNA/análise; DNA/genética; DNA/metabolismo; Reparo do DNA; Humanos; Oligonucleotídeos; Especificidade por Substrato; Espectrometria de Massas em Tandem; Timina/metabolismo; Timina DNA Glicosilase/análise; Timina DNA Glicosilase/genética; Timina DNA Glicosilase/metabolismo; Uracila/química

Palavras-chave

DNA damage; DNA repair; cytosine; deamination; glycosylase; mass spectrometry; mutation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Timina DNA Glicosilase Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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