Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation.

Pearson, David; Jin, Yi; Romeo, Andrea; Birlinger, Bertrand-Luc; Schiller, Hilmar; Ji, Yan; Gunduz, Mithat; Baldoni, Daniela; Walles, Markus

Pearson, David; Jin, Yi; Romeo, Andrea; Birlinger, Bertrand-Luc; Schiller, Hilmar; Ji, Yan; Gunduz, Mithat; Baldoni, Daniela; Walles, Markus.

Afiliação

Pearson D; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Jin Y; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Romeo A; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Birlinger BL; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Schiller H; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Ji Y; Novartis Institutes for Biomedical Research, East Hanover, NJ, USA.
Gunduz M; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
Baldoni D; Novartis Institutes for Biomedical Research, Basel, Switzerland.
Walles M; Novartis Institutes for Biomedical Research, Basel, Switzerland.

Xenobiotica ; 52(1): 26-37, 2022 Jan.

Article em En | MEDLINE | ID: mdl-35098863

Assuntos

Fígado; Receptores de Estrogênio; Animais; Hepatócitos/metabolismo; Humanos; Fígado/metabolismo; Ratos; Receptores de Estrogênio/metabolismo; Tiofenos/metabolismo

Palavras-chave

LSZ102; SERD; SULT; selective oestrogen receptor degrader; sulfotranferase

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Estrogênio / Fígado Limite: Animals / Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Suíça

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google