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The NEDD8-activating enzyme inhibitor MLN4924 reduces ischemic brain injury in mice.
Yu, Huilin; Luo, Haiyu; Chang, Luping; Wang, Shisheng; Geng, Xue; Kang, Lijing; Zhong, Yi; Cao, Yongliang; Wang, Ranran; Yang, Xing; Zhu, Yuanbo; Shi, Mei-Juan; Hu, Yue; Liu, Zhongwang; Yin, Xuhui; Ran, Yunwei; Yang, Hao; Fan, Wenying; Zhao, Bing-Qiao.
Afiliação
  • Yu H; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Luo H; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Chang L; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Wang S; Institutes for Systems Genetics and NHC Key Lab of Transplant Engineering and Immunology, Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Geng X; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Kang L; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Zhong Y; Institutes for Systems Genetics and NHC Key Lab of Transplant Engineering and Immunology, Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Cao Y; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Wang R; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Yang X; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Zhu Y; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Shi MJ; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Hu Y; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Liu Z; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
  • Yin X; Institute of Neuroscience and Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
  • Ran Y; Institute of Neuroscience and Third Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
  • Yang H; Institutes for Systems Genetics and NHC Key Lab of Transplant Engineering and Immunology, Sichuan Provincial Engineering Laboratory of Pathology in Clinical Application, West China Hospital, Sichuan University, Chengdu 610041, China; bingqiaoz@fudan.edu.cn wenyingf@fudan.edu.cn yanghao@scu.edu.cn.
  • Fan W; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; bingqiaoz@fudan.edu.cn wenyingf@fudan.edu.cn yanghao
  • Zhao BQ; Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China; bingqiaoz@fudan.edu.cn wenyingf@fudan.edu.cn yanghao
Proc Natl Acad Sci U S A ; 119(6)2022 02 08.
Article em En | MEDLINE | ID: mdl-35101976
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Lesões Encefálicas / Isquemia Encefálica / Processamento de Proteína Pós-Traducional / Ciclopentanos / Ubiquitina-Proteína Ligases / Proteína NEDD8 / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Lesões Encefálicas / Isquemia Encefálica / Processamento de Proteína Pós-Traducional / Ciclopentanos / Ubiquitina-Proteína Ligases / Proteína NEDD8 / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China