AA, amino acids; AAD, aortic aneurysm and dissection; AKT, protein kinase B; AMPK, AMP-activated protein kinase; ATP, adenosine triphosphate; Ang II, angiotensin II; CBD, C-binding domain; CDG, c-di-GMP; CDNs, cyclic dinucleotides; CTD, C-terminal domain; CTT, C-terminal tail; CVDs, cardiovascular diseases; Cardiovascular diseases; Cys, cysteine; DAMPs, danger-associated molecular patterns; Damage-associated molecular patterns; DsbA-L, disulfide-bond A oxidoreductase-like protein; ER stress; ER, endoplasmic reticulum; GTP, guanosine triphosphate; HAQ, R71H-G230A-R293Q; HFD, high-fat diet; ICAM-1, intracellular adhesion molecule 1; IFN, interferon; IFN-I, type 1 interferon; IFNAR, interferon receptors; IFNIC, interferon-inducible cells; IKK, IκB kinase; IL, interleukin; IRF3, interferon regulatory factor 3; ISGs, IRF-3-dependent interferon-stimulated genes; Inflammation; LBD, ligand-binding pocket; LPS, lipopolysaccharides; MI, myocardial infarction; MLKL, mixed lineage kinase domain-like protein; MST1, mammalian Ste20-like kinases 1; Metabolic diseases; Mitochondria; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; NF-κB, nuclear factor-kappa B; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3; NO2-FA, nitro-fatty acids; NTase, nucleotidyltransferase; PDE3B/4, phosphodiesterase-3B/4; PKA, protein kinase A; PPI, protein­protein interface; Poly: I.C, polyinosinic-polycytidylic acid; ROS, reactive oxygen species; SAVI, STING-associated vasculopathy with onset in infancy; SNPs, single nucleotide polymorphisms; STIM1, stromal interaction molecule 1; STING; STING, stimulator of interferon genes; Ser, serine; TAK1, transforming growth factor ß-activated kinase 1; TBK1, TANK-binding kinase 1; TFAM, mitochondrial transcription factor A; TLR, Toll-like receptors; TM, transmembrane; TNFα, tumor necrosis factor-alpha; TRAF6, tumor necrosis factor receptor-associated factor 6; TREX1, three prime repair exonuclease 1; YAP1, Yes-associated protein 1; cGAMP, 2',3'-cyclic GMP­AMP; cGAS; cGAS, cyclic GMP­AMP synthase; dsDNA, double-stranded DNA; hSTING, human stimulator of interferon genes; mTOR, mammalian target of rapamycin; mtDNA, mitochondrial DNA