Efficient access to 1,3,4-trisubstituted pyrroles <i>via</i> gold-catalysed cycloisomerization of 1,5-diynes.

Wan, Qiuling; Xin, Luoting; Zhang, Jian; Huang, Xueliang

Efficient access to 1,3,4-trisubstituted pyrroles via gold-catalysed cycloisomerization of 1,5-diynes.

Wan, Qiuling; Xin, Luoting; Zhang, Jian; Huang, Xueliang.

Afiliação

Wan Q; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, Fujian 350007, P. R. China.
Xin L; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China. zhj@fjirsm.ac.cn.
Zhang J; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China. zhj@fjirsm.ac.cn.
Huang X; Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 4100

Org Biomol Chem ; 20(8): 1647-1651, 2022 02 23.

Article em En | MEDLINE | ID: mdl-35137761

RESUMO

A gold-catalysed cycloisomerization of 1,5-diynes is described, which offers a selective approach to access 1,3,4-trisubstituted pyrroles. In this reaction, the cationic gold catalyst activates the ynamide moiety, initiating the cycloisomerization to produce the pyrrole core, and H2O acts as an external nucleophile to trap the vinyl cationic species, thus leading to the formation of 1,3,4-trisubstituted pyrroles with high selectivity.

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google