Lysosomal gene <i>Hexb</i> displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease.

Whyte, Lauren S; Fourrier, Célia; Hassiotis, Sofia; Lau, Adeline A; Trim, Paul J; Hein, Leanne K; Hattersley, Kathryn J; Bensalem, Julien; Hopwood, John J; Hemsley, Kim M; Sargeant, Timothy J

Lysosomal gene Hexb displays haploinsufficiency in a knock-in mouse model of Alzheimer's disease.

Whyte, Lauren S; Fourrier, Célia; Hassiotis, Sofia; Lau, Adeline A; Trim, Paul J; Hein, Leanne K; Hattersley, Kathryn J; Bensalem, Julien; Hopwood, John J; Hemsley, Kim M; Sargeant, Timothy J.

Afiliação

Whyte LS; The University of Adelaide, School of Medicine, North Terrace, Adelaide, SA, Australia.
Fourrier C; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Hassiotis S; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Lau AA; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Trim PJ; The University of Adelaide, School of Medicine, North Terrace, Adelaide, SA, Australia.
Hein LK; Childhood Dementia Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Hattersley KJ; Proteomics, Metabolomics and MS-Imaging Core Facility, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Bensalem J; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Hopwood JJ; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Hemsley KM; Lysosomal Health in Ageing, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.
Sargeant TJ; The University of Adelaide, School of Medicine, North Terrace, Adelaide, SA, Australia.

IBRO Neurosci Rep ; 12: 131-141, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35146484

Palavras-chave

AD, Alzheimer's disease; APP, amyloid precursor protein; Alzheimer's disease; AppNL-G-F/NL-G-F; Aß, amyloid beta; CD68, cluster of differentiation 68; Dementia; ELISA, enzyme-linked immunosorbent assay; GFAP, glial fibrillary acidic protein; HEXB, ß-hexosaminidase ß subunit; Hexb; IBA1, ionised calcium binding adaptor molecule 1; IL, interleukin; Knock-in; LAMP1, lysosome associated membrane protein 1; LSDs, lysosomal storage disorders; Lysosome; PBS, phosphate buffered saline; TREM2, triggering receptor expressed on myeloid cells 2; ß-hexosaminidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: IBRO Neurosci Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália

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