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Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.
Ravi, Nithin Sam; Wienert, Beeke; Wyman, Stacia K; Bell, Henry William; George, Anila; Mahalingam, Gokulnath; Vu, Jonathan T; Prasad, Kirti; Bandlamudi, Bhanu Prasad; Devaraju, Nivedhitha; Rajendiran, Vignesh; Syedbasha, Nazar; Pai, Aswin Anand; Nakamura, Yukio; Kurita, Ryo; Narayanasamy, Muthuraman; Balasubramanian, Poonkuzhali; Thangavel, Saravanabhavan; Marepally, Srujan; Velayudhan, Shaji R; Srivastava, Alok; DeWitt, Mark A; Crossley, Merlin; Corn, Jacob E; Mohankumar, Kumarasamypet M.
Afiliação
  • Ravi NS; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Wienert B; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
  • Wyman SK; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
  • Bell HW; Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, United States.
  • George A; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
  • Mahalingam G; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
  • Vu JT; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.
  • Prasad K; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Bandlamudi BP; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
  • Devaraju N; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Rajendiran V; Innovative Genomics Institute, University of California, Berkeley, Berkeley, United States.
  • Syedbasha N; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Pai AA; Manipal Academy of Higher Education, Karnataka, India.
  • Nakamura Y; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Kurita R; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Narayanasamy M; Manipal Academy of Higher Education, Karnataka, India.
  • Balasubramanian P; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Thangavel S; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
  • Marepally S; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Velayudhan SR; Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India.
  • Srivastava A; Department of Haematology, Christian Medical College & Hospital, Vellore, India.
  • DeWitt MA; Cell Engineering Division, RIKEN BioResource Center, Ibaraki, Japan.
  • Crossley M; Research and Development Department, Central Blood Institute Blood Service Headquarters, Japanese Red Cross Society, Japan, Tokyo, Japan.
  • Corn JE; Centre for Stem Cell Research (a Unit of inStem, Bengaluru), Christian Medical College Campus, Vellore, India.
  • Mohankumar KM; Department of Biochemistry, Christian Medical College, Vellore, India.
Elife ; 112022 02 11.
Article em En | MEDLINE | ID: mdl-35147495
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Sistemas CRISPR-Cas / Edição de Genes / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Sistemas CRISPR-Cas / Edição de Genes / Anemia Falciforme Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Elife Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia