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Epidemiological, Clinical, and Phylogenetic Characteristics of the First SARS-CoV-2 Transmission in a Nursing Home of Singapore: A Prospective Observational Investigation.
Pang, Junxiong; Tan, Huei Nuo; Mak, Tze Minn; Octavia, Sophie; Maurer-Stroh, Sebastian; Sirota, Fernanda L; Chan, Mark Peng Chew; Leong, Ian Yi Onn; Koh, Valerie T J; Ooi, Peng Lim; Vasoo, Shawn; Fisher, Dale; Cui, Lin; Rafman, Heidi; Cutter, Jeffery; Lee, Vernon J.
Afiliação
  • Pang J; Ministry of Health, Singapore, Singapore.
  • Tan HN; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Mak TM; Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
  • Octavia S; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Maurer-Stroh S; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Sirota FL; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore, Singapore.
  • Chan MPC; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Leong IYO; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
  • Koh VTJ; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Ooi PL; Genome Institute of Singapore and Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Vasoo S; Department of Geriatric Medicine, Tan Tock Seng Hospital, Singapore, Singapore.
  • Fisher D; Division of Central Health, Tan Tock Seng Hospital, Singapore, Singapore.
  • Cui L; Ministry of Health, Singapore, Singapore.
  • Rafman H; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
  • Cutter J; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore, Singapore.
  • Lee VJ; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore, Singapore.
Front Med (Lausanne) ; 8: 790177, 2021.
Article em En | MEDLINE | ID: mdl-35155470
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission has resulted in a significant burden among nursing home facilities globally. This prospective observational cohort study aims to define the potential sources of introduction and characteristics of SARS-CoV-2 transmission of the first nursing home facility in Singapore. An epidemiological serial point-prevalence survey of SARS-CoV-2 was conducted among 108 residents and 56 healthcare staff (HCS). In the current study, 14 (13%) residents and two (3.6%) HCS were diagnosed with coronavirus disease 2019 (COVID-19), with a case fatality rate (CFR) of 28.6% (4/14) among the residents. The median age of the infected residents was 86.5 [interquartile range (IQR) 78.5-88] and 85.7% were women. Five residents were symptomatic (35.7%) and the others were asymptomatic (64.3%). A higher proportion of residents who succumbed to COVID-19 had hypertension than those who recovered. The SARS-CoV-2 whole-genome sequencing showed lineage B.6 which is rare globally but common regionally during the early phase of the pandemic. Household transmission is a potential source of introduction into the nursing home, with at least six epidemiologically linked secondary cases. Male residents were less implicated due to the staff segregation plan by block. Among residents, a higher proportion of the non-survivors were asymptomatic and had hypertension compared with survivors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Observational_studies / Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Singapura