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Design and synthesis of novel spirocyclic carboxylic acids as potent and orally bioavailable DGAT1 inhibitors and their biological evaluation.
Koul, Summon; Kurhade, Suresh; Bhosale, Sandeep; Naik, Keshav; Salunkhe, Videsh; Ravula, Sudhir; Punde, Prasad; Velayutham, Ravikumar; Tiwari, Atul; Ahl, Daniela; Malkapuram, Srividya; Mudagala, Vamsi; Raje, Amol; Umrani, Dhananjay; Tambe, Suhas; Patil, Poonam; Singh, Umesh; Bhuniya, Debnath; Hariharan, Narayanan; Mookhtiar, Kasim.
Afiliação
  • Koul S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India; School of Consciousness, Dr.Vishwanath Karad MIT World Peace University, Pune, Maharashtra 411038, India. Electronic address: summon.koul@mitwpu.edu.in.
  • Kurhade S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Bhosale S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Naik K; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Salunkhe V; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Ravula S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Punde P; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Velayutham R; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Tiwari A; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Ahl D; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Malkapuram S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Mudagala V; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Raje A; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Umrani D; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Tambe S; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Patil P; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Singh U; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Bhuniya D; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Hariharan N; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
  • Mookhtiar K; Department of Discovery Chemistry, Discovery Biology and DMPK, Advinus Therapeutics. Ltd., Hinjewadi, Pune 411 057, India.
Bioorg Med Chem Lett ; 62: 128632, 2022 04 15.
Article em En | MEDLINE | ID: mdl-35189320
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Carboxílicos / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Carboxílicos / Inibidores Enzimáticos / Diacilglicerol O-Aciltransferase Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article