Coinheritance of HbO Arab/ß0-thalassemia with Severe Manifestation in Newborn.
Am J Perinatol
; 2022 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-35189650
ABSTRACT
OBJECTIVE:
In this study, we report a Tunisian newborn boy referred for neonatal hemolytic anemia with yellowish skin and enlarged spleen due to coinheritance of hemoglobin O (HbO) Arab and ß-thalassemia. STUDYDESIGN:
Hematological parameters were collected using an automated blood cell counter. The amounts of Hb fractions were measured by capillary electrophoresis of Hb. Amplification and sequencing of the HBB gene were performed by Sanger's method.RESULTS:
Family study and genetic analysis revealed that the proband was a carrier of two hemoglobinopathies HbO Arab and ß0-thalassemia.CONCLUSION:
The coexistence of these two pathologies complicated the general state of the newborn boy and led to a severe anemia at birth. KEY POINTS · Severe neonatal anemia can be caused by hemoglobinopathy.. · Coinheritance of HbO Arab/ß0-thalassemia complicated the general state of the newborn.. · Diagnosing hemoglobinopathy at an early age improves patient care..
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Am J Perinatol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Tunísia