Repetitive expanded T-cell receptor clonotypes impart the classic T helper 2 Sézary cell phenotype.

Jiang, Tony T; Kruglov, Oleg; Geskin, Larisa; Akilov, Oleg E

Jiang, Tony T; Kruglov, Oleg; Geskin, Larisa; Akilov, Oleg E.

Afiliação

Jiang TT; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
Kruglov O; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.
Geskin L; Department of Dermatology, Columbia University, New York, NY, USA.
Akilov OE; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.

Br J Dermatol ; 187(2): 265-267, 2022 08.

Article em En | MEDLINE | ID: mdl-35191024

ABSTRACT

ABSTRACT

Six out of 12 Sézary patients shared one clonotype (TRAV13-1*01-TRAJ49*01-TRBV20-1*01-TRBJ2-3*01). TRBV20-1*01 (also known as Vb2) that binds toxic shock syndrome toxin-1 was utilized by Sézary cells among half of the cohort, which would be expected for a common unifying origin.

Assuntos

Síndrome de Sézary; Neoplasias Cutâneas; Humanos; Linfócitos; Fenótipo; Receptores de Antígenos de Linfócitos T/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Síndrome de Sézary Limite: Humans Idioma: En Revista: Br J Dermatol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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